Diabetic neuropathies: features and mechanisms.

  title={Diabetic neuropathies: features and mechanisms.},
  author={Douglas W Zochodne},
  journal={Brain pathology},
  volume={9 2},
Diabetic neuropathies include both focal neuropathies and diffuse polyneuropathy. Polyneuropathy, the most common of the diabetic neuropathies excluding focal entrapment, has not yet been explained by a single disease mechanism despite intensive investigation. A number of abnormalities appear to cascade into a 'vicious cycle' of progressive microvascular disease associated with motor, sensory and autonomic fiber loss. These abnormalities include excessive polyol (sugar alcohol) flux through the… CONTINUE READING


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