Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.

  title={Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.},
  author={Hanning You and Ting Gao and Timothy K. Cooper and Sidney M Morris and Alaa S. Awad},
  journal={American journal of physiology. Renal physiology},
  volume={307 11},
Our recent publication showed that pharmacological blockade of arginases confers kidney protection in diabetic nephropathy via a nitric oxide (NO) synthase (NOS)3-dependent mechanism. Arginase competes with endothelial NOS (eNOS) for the common substrate L-arginine. Lack of L-arginine results in reduced NO production and eNOS uncoupling, which lead to endothelial dysfunction. Therefore, we hypothesized that L-arginine or L-citrulline supplementation would ameliorate diabetic nephropathy. DBA… CONTINUE READING
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