Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles1[S]

  title={Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles1[S]},
  author={Kerri J Grove and Paul A. Voziyan and Jeffrey M. Spraggins and Su-wan Wang and Paisit Paueksakon and Raymond C. Harris and Billy G. Hudson and Richard M. Caprioli},
  journal={Journal of Lipid Research},
  pages={1375 - 1385}
Diabetic nephropathy (DN) is a major life-threatening complication of diabetes. Renal lesions affect glomeruli and tubules, but the pathogenesis is not completely understood. Phospholipids and glycolipids are molecules that carry out multiple cell functions in health and disease, and their role in DN pathogenesis is unknown. We employed high spatial resolution MALDI imaging MS to determine lipid changes in kidneys of eNOS−/− db/db mice, a robust model of DN. Phospholipid and glycolipid… 

Urinary lysophopholipids are increased in diabetic patients with nephropathy.

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Renal Lipid Metabolism and Lipotoxicity in Diabetes.

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Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effects of rapamycin.

  • Guangyi LiuF. Han Jianghua Chen
  • Biology, Chemistry
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2011
Accumulation of sphingolipids contributes to STZ-induced diabetes, and the therapeutic effect of rapamycin on diabetic nephropathy is partly through suppression of spindingolipid abnormality.

Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat.

Pyridoxamine inhibits the progression of renal disease, and decreases hyperlipidemia and apparent redox imbalances in diabetic rats, supporting a mechanism of action involving AGE/ALE inhibition.

Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice.

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Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice.

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a-Series gangliosides mediate the effects of advanced glycation end products on pericyte and mesangial cell proliferation: a common mediator for retinal and renal microangiopathy?

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A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus.

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