Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats.

@article{Bilan2011DiabeticNA,
  title={Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats.},
  author={Victor P. Bilan and Eman M. Salah and Sheldon Bastacky and Huw Bowen Jones and Rachel M Mayers and Bradley A. Zinker and S. M. Poucher and Stevan P Tofovic},
  journal={The Journal of endocrinology},
  year={2011},
  volume={210 3},
  pages={293-308}
}
Diabetic nephropathy (DN) is a major cause of end-stage renal disease. Yet the pathogenic mechanisms underlying the development of DN are not fully defined, partially due to lack of suitable models that mimic the complex pathogenesis of renal disease in diabetic patients. In this study, we describe early and late renal manifestations of DN and renal responses to long-term treatments with rosiglitazone or high-dose enalapril in ZSF1 rats, a model of metabolic syndrome, diabetes, and chronic… CONTINUE READING
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