Diabetic nephropathy: where hemodynamics meets metabolism.

  title={Diabetic nephropathy: where hemodynamics meets metabolism.},
  author={Josephine M Forbes and Kei Fukami and Mark Emmanuel Cooper},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  volume={115 2},
Diabetic nephropathy (DN), the most common cause of end stage renal disease in developed nations, is thought to result from interactions between metabolic and haemodynamic factors. Specific metabolically driven, glucose dependent pathways are activated within diabetic renal tissues. These pathways induce oxidative stress, polyol pathway flux, hexosamine flux and accumulation of advanced glycated end-products (AGEs). Haemodynamic factors are also implicated in the pathogenesis of DN and include… CONTINUE READING


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