Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors.

@article{Tanii2006DiabeticMI,
  title={Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors.},
  author={Mitsugu Tanii and Yoshikazu Yonemitsu and Takaaki Fujii and Yasunori Shikada and Ri-ichiro Kohno and Mitsuho Onimaru and Shinji Okano and Makoto Inoue and Mamoru Hasegawa and Toshihiro Onohara and Yoshihiko Maehara and Katsuo Sueishi},
  journal={Circulation research},
  year={2006},
  volume={98 1},
  pages={55-62}
}
Diabetic foot is caused by microangiopathy and is suggested to be a result of impaired angiogenesis. Using a severe hindlimb ischemia model of streptozotocin-induced diabetic mice (STZ-DM), we show that diabetic foot is a disease solely of the disturbance of platelet-derived growth factor B-chain homodimer (PDGF-BB) expression but not responses of angiogenic factors. STZ-DM mice frequently lost their hindlimbs after induced ischemia, whereas non-DM mice did not. Screening of angiogenesis… CONTINUE READING
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