Diabetic microangiopathy: impact of impaired cerebral vasoreactivity and delayed angiogenesis after permanent middle cerebral artery occlusion on stroke damage and cerebral repair in mice.

@article{Poittevin2015DiabeticMI,
  title={Diabetic microangiopathy: impact of impaired cerebral vasoreactivity and delayed angiogenesis after permanent middle cerebral artery occlusion on stroke damage and cerebral repair in mice.},
  author={Marine Poittevin and Philippe Bonnin and Cynthia Pimpie and L{\'e}a Rivi{\`e}re and Catherine S{\'e}bri{\'e} and Anthony Dohan and Marc Pocard and Christiane Charriaut-Marlangue and Nathalie Kubis},
  journal={Diabetes},
  year={2015},
  volume={64 3},
  pages={999-1010}
}
Diabetes increases the risk of stroke by three, increases related mortality, and delays recovery. We aimed to characterize functional and structural alterations in cerebral microvasculature before and after experimental cerebral ischemia in a mouse model of type 1 diabetes. We hypothesized that preexisting brain microvascular disease in patients with diabetes might partly explain increased stroke severity and impact on outcome. Diabetes was induced in 4-week-old C57Bl/6J mice by intraperitoneal… CONTINUE READING
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