Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.

@article{Herbach2009DiabeticKL,
  title={Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.},
  author={Nadja Herbach and Irene Schairer and Andreas Blutke and Sabine Kautz and Angela Siebert and Burkhard J. G{\"o}ke and Eckhard Wolf and Ruediger Wanke},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={296 4},
  pages={
          F819-29
        }
}
Diabetic nephropathy is the leading cause of end-stage renal disease and the largest contributor to the total cost of diabetes care. Rodent models are excellent tools to gain more insight into the pathogenesis of diabetic nephropathy. In the present study, we characterize the age-related sequence of diabetes-associated kidney lesions in GIPR(dn) transgenic mice, a novel mouse model of early-onset diabetes mellitus. Clinical-chemical analyses as well as qualitative and quantitative morphological… CONTINUE READING

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