Diabetic kidney disease: from physiology to therapeutics.

  title={Diabetic kidney disease: from physiology to therapeutics.},
  author={Carmen Mora-Fern{\'a}ndez and Virginia Dom{\'i}nguez-Pimentel and Mercedes Muros de Fuentes and Jos{\'e} Luis G{\'o}rriz and Alberto Mart{\'i}nez-Castelao and Juan F Navarro-Gonz{\'a}lez},
  journal={The Journal of physiology},
  volume={592 18},
Diabetic kidney disease (DKD) defines the functional, structural and clinical abnormalities of the kidneys that are caused by diabetes. This complication has become the single most frequent cause of end-stage renal disease. The pathophysiology of DKD comprises the interaction of both genetic and environmental determinants that trigger a complex network of pathophysiological events, which leads to the damage of the glomerular filtration barrier, a highly specialized structure formed by the… CONTINUE READING