Diabetic ketoacidosis elicits systemic inflammation associated with cerebrovascular endothelial cell dysfunction.

Abstract

OBJECTIVE To determine if the DKA-induced inflammation in juvenile mice provokes activation and dysfunction of CVECs. METHODS DKA in juvenile mice was induced with administration of STZ and ALX. Blood from DKA mice was assessed for cytokines and soluble cell adhesion proteins, and either DKA plasma or exogenous compounds were applied to immortalized bEND3… (More)
DOI: 10.1111/micc.12053

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