Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals.

  title={Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals.},
  author={Galen M. Pieper and Peter Langenstroer and Wolfgang Siebeneich},
  journal={Cardiovascular research},
  volume={34 1},
OBJECTIVE Previous studies suggest a role of superoxide anion radicals (.O2-) in impaired endothelium-dependent relaxation of diabetic blood vessels; however, the role of secondary reactive oxygen species remains unclear. In the present study, we investigated a role of various potential reactive oxygen species in diabetic endothelial dysfunction. METHODS Thoracic aortic rings from 8-week streptozotocin-induced diabetic and age-matched control rats were mounted in isolated tissue baths… CONTINUE READING


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Oxidative stress in diabetic blood vessels

GM Pieper
FASEB J Ž • 1995

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