Diabetic foot infection: Bacteriological causes and antimicrobial therapy


Background: Diabetic foot is one of the most serious complications of diabetes and is the leading cause of hospitalization in diabetic patients. This study was done to determine the common aerobic bacterial causes of diabetic foot infections and there in vitro antibiotic susceptibility pattern in Sohag University hospitals. Methods: A prospective study was performed over a period of one year in Sohag University Hospitals. The aerobic bacterial agents were isolated and their antibiotic susceptibility pattern was determined by the disc diffusion method. Members of Enterobacteriaceae were tested for extended spectrum ß-lactamase (ESBL) production by combination disc method and staphylococcal isolates were tested for susceptibility to oxacillin by screen agar method. Results: Escherichia coli (20.3%), Klebsiella pneumoniae (17.4%), Staphylococcus aureus (16.2%), and Pseudomonas aeruginosa (12.6%) were the most common bacterial causes of DFIs. Polymicrobial infection was observed in 39.1% of the patients. The members of Enterobacteriaceae as well as Pseudomonas spp. and Acinetobacter spp. were found to be susceptible mainly to imipenem, levofloxacin and amikacin. Staphylococcus aureus and Enterococcus spp. were susceptible mostly to vancomycin, levofloxacin, and ciprofloxacin with varying susceptibility to tetracycline. 80% of the isolates belonging to Enterobacteriaceae were producing ESBL and 67% of Staphylococcus aureus were methicillin-resistant. Conclusion: High prevalence of multi-drug resistant pathogens was observed. imipenem, levofloxacin and amikacin were active against gram-negative bacilli, while vancomycin, levofloxacin and ciprofloxacin were found to be active against gram-positive bacteria [Mamdouh M. Esmat and Ahmed Saif Al Islam Diabetic foot infection: Bacteriological causes and antimicrobial therapy. J Am Sci 2012;8 (10):389-393]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 57

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@inproceedings{Esmat2012DiabeticFI, title={Diabetic foot infection: Bacteriological causes and antimicrobial therapy}, author={Mamdouh M. Esmat and Ahmed Saif Al Islam}, year={2012} }