Diabetic endothelial dysfunction: effect of free radical scavenging in Type 2 diabetic patients.

@article{DeMattia2003DiabeticED,
  title={Diabetic endothelial dysfunction: effect of free radical scavenging in Type 2 diabetic patients.},
  author={Giancarlo De Mattia and Oriana Laurenti and Danila Fava},
  journal={Journal of diabetes and its complications},
  year={2003},
  volume={17 2 Suppl},
  pages={
          30-5
        }
}
Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice.
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Results suggest that augmented SOD2 ubiquitination leads to the increase in mitochondrial ROS concentration in coronary ECs from T2D mice and attenuates coronary vascular relaxation in T1D mice.
The Protective Effect of Renin-Angiotensin-Aldosterone System Inhibitors in STZ- Induced Diabetes Mellitus in Rats
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High glucose causes endothelial oxidative stress and dysfunction via Nox2-induced ROS production, which causes ECs cycle deregulation, cell apoptosis and capillaries broken down on matrigels, according to cultured human pulmonary microvascular ECs.
Interleukin-6 and Oxidative Stress in Plasma of Alloxan-Induced Diabetic Rabbits after Pioglitazone Treatment
TLDR
The results obtained in the present study confirm the relations of cytokine systems with oxidative stress in plasma of diabetic subjects and suggest the antioxidative and antinflammatory properties of pioglitazone.
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The results suggest the possible effectiveness of aldose reductase and arginase inhibitors in the management of diabetic vascular and behavioral complications together with conventional antidiabetic therapy.
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TLDR
In vivo and in vitro results showed that the combination of captopril or losartan with gliclazide results in significant decrease in serum glucose, increase in serum insulin, increase liver glycogen content and improvement of oxidative stress parameters.
Role of nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic vascular dysfunction.
TLDR
The mechanism by which hyperglycaemia induces nitrosative stress and the role PARP activation plays in diabetic vascular dysfunction are focused on.
Diabetic nephropathy and multiorgan protection. Part II.
TLDR
The first part of the paper presented the concept of multiorgan protection, as well as some of the main protective measures: control of blood pressure mainly by means of inhibitors of the renine angiotensine aldosterone system, glycaemia monitoring and antiproteinuric treatment.
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TLDR
The suggestion that the different susceptibility of diabetic patients to microvascular and macrovascular complications may be a function of the endogenous antioxidant status is suggested.
Nitric oxide availability in diabetes mellitus.
TLDR
Understanding of the complex metabolic disturbances interacting with the NO system may provide us with further therapeutic options to decrease cardiovascular morbidity and mortality in diabetes mellitus.
In vitro and in vivo antioxidant properties of gliclazide.
Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
TLDR
It is concluded that endothelial dysfunction in forearm resistance vessels of patients with non-insulin-dependent diabetes mellitus can be improved by administration of the antioxidant, vitamin C, and support the hypothesis that nitric oxide inactivation by oxygen-derived free radicals contributes to abnormal vascular reactivity in diabetes.
Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
TLDR
The data suggest that the chronic deficit in nitric oxide-mediated endothelium-dependent relaxation in diabetes depends largely upon excess activity of reactive oxygen species, and treatment with vitamin E to increase free radical scavenging specifically protected vascular endothelia although it had no effect on deficits in vascular smooth muscle contractile responses.
Gliclazide scavenges hydroxyl, superoxide and nitric oxide radicals: an ESR study.
TLDR
It is suggested that gliclazide is not only effective in reducing blood sugar but also may be beneficial by inhibition of lipid and protein denaturation, which leads to the development of diabetic complications.
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