Diabetic complications in a new animal model (TSOD mouse) of spontaneous NIDDM with obesity.

@article{Iizuka2005DiabeticCI,
  title={Diabetic complications in a new animal model (TSOD mouse) of spontaneous NIDDM with obesity.},
  author={Seiichi Iizuka and Wataru Suzuki and Masahiro Tabuchi and Mitsunobu Nagata and Sachiko Imamura and Yujiro Kobayashi and Masanao Kanitani and Toshihiko Yanagisawa and Yoshio Kase and Shuichi Takeda and Masaki Aburada and Kazuaki Takahashi},
  journal={Experimental animals},
  year={2005},
  volume={54 1},
  pages={71-83}
}
The TSOD mouse has been established as an inbred strain with spontaneous development of diabetes mellitus as the first clinical signs of diabetes. Polydipsia and polyuria are observed at about 2 months old only in male mice, after which hyperglycemia and hyperinsulinemia are detected. Following these symptoms obesity gradually develops until about 12 months old. In histopathological examination of the pancreas, severe hypertrophy of pancreatic islets was observed due to proliferation and… CONTINUE READING
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