Diabetic cataract formation: potential role of glycosylation of lens crystallins.

@article{Stevens1978DiabeticCF,
  title={Diabetic cataract formation: potential role of glycosylation of lens crystallins.},
  author={Victor J. Stevens and Carol A. Rouzer and Vincent M. Monnier and Anthony Cerami},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 6},
  pages={2918-22}
}
A high glucose concentration in vivo or an increased glucose of glucose 6-phosphate concentration in vitro has been found to lead to the glycosylation of epsilon-amino groups of lysine residues in bovine and rat lens crystallins. In vitro, this glycosylation imparts an increased susceptibility of the crystallins to sulfhydryl oxidation. Disulfide crosslinks… CONTINUE READING