Diabetic cardiomyopathy revisited.

@article{Boudina2007DiabeticCR,
  title={Diabetic cardiomyopathy revisited.},
  author={Sihem Boudina and Evan Dale Abel},
  journal={Circulation},
  year={2007},
  volume={115 25},
  pages={
          3213-23
        }
}
Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the… 
View on PubMed
ahajournals.org
1,411 Citations
Highly Influential Citations
52
Background Citations
520
Methods Citations
16
Results Citations
13

1,411 Citations

Citation Type

Citation Type

Diabetic cardiomyopathy, causes and effects
TLDR
The discussion will be focused on the structural, functional and metabolic changes that occur in the myocardium in diabetes and how these changes may contribute to the development of diabetic cardiomyopathy in affected humans and relevant animal models.
Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets.
Non ischemic heart failure in diabetes mellitus: still incompletely understood
TLDR
It is proposed that heart failure in diabetes can be traced to alterations in whole-body energy homeostasis * and myocardial metabolism.
Diabetes and Cardiac Mitochondria
TLDR
There is evidence indicating that mitochondrial dysfunction is critical in the pathogenesis of diabetic cardiomyopathy, one of the leading causes of heart failure among diabetic patients.
The complexities of diabetic cardiomyopathy: Lessons from patients and animal models
TLDR
The recent advances in the domain confirm that the disease is above all a maladaptation of the heart mostly driven by the metabolic derangements that accompany diabetes mellitus.
Calcium-Handling Proteins in Diabetic Cardiomyopathy
TLDR
It is widely recognized that cardiac dysfunction in chronic diabetes involves hormonal imbalance, oxidative stress, proteases activation, defects in Ca2+ cycling, and varying degrees of subcellular remodeling of organelles.
Mitochondrial Dysfunction in Diabetic Cardiomyopathy
TLDR
Evaluating mechanisms for the mitochondrial abnormalities that may be involved in the development and progression of cardiac dysfunction in diabetes is focused on evaluating the role of myocardial mitochondrial dysfunction.
Clinical manifestations of diabetic cardiomyopathy
TLDR
The discussion will be focused on the structural, functional, and metabolic changes that occur in the diabetic myocardium and how these changes contribute to the development of DCM in humans.
Diabetic cardiomyopathy: myth or reality?
Diabetic Cardiomyopathy: A Forensic Perspective
TLDR
This entity may be implicated as the cause of sudden cardiac death in the small percentage of diabetic patients in which the autopsy fails to demonstrate evidence of nonketotic hyperosmolar coma, diabetic ketoacidosis, or atherosclerotic and hypertensive cardiovascular disease.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 198 REFERENCES
Alterations in ion channel physiology in diabetic cardiomyopathy.
Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.
TLDR
Evidence is presented that diabetes is associated with a cardiomyopathy, independent of comorbid conditions, and that metabolic disturbances, myocardial fibrosis, small vessel disease, cardiac autonomic neuropathy, and insulin resistance may all contribute to the development of diabetic heart disease.
Role of changes in cardiac metabolism in development of diabetic cardiomyopathy.
  • D. An, B. Rodrigues
  • Medicine, Biology
    American journal of physiology. Heart and circulatory physiology
  • 2006
TLDR
Evaluating the acute and chronic regulation and dysregulation of cardiac metabolism in normal and insulin-resistant/diabetic hearts and how these changes could contribute toward the development of cardiomyopathy is evaluated.
Epidemiology of the diabetic heart
TLDR
Prevention of diabetes and its prediabetic states is likely to be the most effective strategy to prevent serious cardiovascular events within the diabetes epidemic.
Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths
Diabetic cardiomyopathy: recent evidence from mouse models of type 1 and type 2 diabetes.
  • D. Severson
  • Medicine, Biology
    Canadian journal of physiology and pharmacology
  • 2004
TLDR
Both systolic dysfunction and diastolic dysfunction is observed in diabetic hearts, along with enhanced susceptibility to ischemic injury, andabolism is also altered in diabetic mouse hearts: glucose utilization is reduced and fatty acid utilization is increased.
Metabolic Abnormalities in the Diabetic Heart
TLDR
The evidence linking alterations in energy metabolism to alterations in contractile function in the diabetic is reviewed to show that changes within the heart itself, caused by diabetes, contributes to congestive heart failure.
Role of diabetes in congestive heart failure: the Framingham study.
Myocardial Cell Death in Human Diabetes
TLDR
The renin-angiotensin system is upregulated with diabetes, and this may contribute to the development of a dilated myopathy, and apoptosis and necrosis were measured in ventricular myocardial biopsies obtained from diabetic and diabetic-hypertensive patients.
Left Ventricular Diastolic Dysfunction as an Early Manifestation of Diabetic Cardiomyopathy
TLDR
Investigating whether young patients with insulin-dependent diabetes mellitus and normal systolic left ventricular (LV) function already show a diastolic LV dysfunction and an increased risk of arrhythmias found echocardiography with measurements of diastolics functional parameters appears to be a sensitive method for evaluating the manifestation and course of early diabetic cardiomyopathy.
...
1
2
3
4
5
...