Diabetic Renal Failure and Serum Accumulation of the Creatinine Oxidative Metabolites Creatol and Methylguanidine

@article{Nakamura1996DiabeticRF,
  title={Diabetic Renal Failure and Serum Accumulation of the Creatinine Oxidative Metabolites Creatol and Methylguanidine},
  author={Kazuhide Nakamura and Kazuharu Ienaga and Koji Nakano and Masako Nakai and Yoshio Nakamura and Goji Hasegawa and Michio Sawada and Motoharu Kondo and Hidezo Mori and Takahiro Kanatsuna},
  journal={Nephron},
  year={1996},
  volume={73 4},
  pages={520-5}
}
Diabetic patients (n = 23) with chronic renal failure (CRF) accumulate the creatinine (Cr) oxidative metabolites creatol (CTL) and methylguanidine (MG; a uremic toxin) in their sera. Analysis of serum CTL, a key intermediate in mammalian Cr catabolism into MG, is shown to offer some useful diagnostic information on CRF, especially in the determination of an initial stage of pathological renal failure. The sera of all diabetic (n = 23) and nondiabetic (n = 20) patients with CRF (s-Cr > 1.25 mg… CONTINUE READING