Diabetes mellitus induces changes in cardiac myosin of the rat.

  title={Diabetes mellitus induces changes in cardiac myosin of the rat.},
  author={Wolfgang H. Dillmann},
  volume={29 7},
'^ I. SUMMARY Decreased contractility has been reported in the diabetic heart. Because a close correlation exists between contractility and the activity of Ca ATPase of purified actinomyosin and myosin, Ca ATPase activity was determined in control and diabetic rats. In control rats, actinomyosin ATPase was 0.59 ± 0.05 /xmol Pi/mg protein/min and had decreased by 35% to 0.38 ± 0.04 in diabetic rats (P < 0.025). Myosin ATPase activity was 1.25 ± 0.09 /xmol Pi/mg protein/min in control rats and… CONTINUE READING
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