Diabetes mellitus increases endothelin-1 gene transcription in rat kidney.

  title={Diabetes mellitus increases endothelin-1 gene transcription in rat kidney.},
  author={G M Hargrove and Julie Dufresne and Catharine Whiteside and Daniel A Muruve and Norman C. W. Wong},
  journal={Kidney international},
  volume={58 4},
BACKGROUND Mesangial cell hypertrophy and increased extracellular matrix (ECM) contribute to mesangial expansion in early progressive diabetic nephropathy. Previous studies suggest that the growth factor endothelin-1 (ET-1) is not only up-regulated in diabetes, but may mediate the effects of hyperglycemia on mesangial cell hypertrophy and ECM synthesis. In models of diabetes mellitus, the mechanisms underlying increased ET-1 peptide and mRNA remain unknown. Therefore, our purpose is to… CONTINUE READING


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