Diabetes mellitus downregulates expression of connexin43 in rat aortic medial smooth muscle cells and can be reversed by simvastatin and losartan therapy.

@article{Sheu2008DiabetesMD,
  title={Diabetes mellitus downregulates expression of connexin43 in rat aortic medial smooth muscle cells and can be reversed by simvastatin and losartan therapy.},
  author={Jiunn-Jye Sheu and Tzu-hsien Tsai and Li-Teh Chang and Chiang-Hua Chiang and Ali Ahmed Youssef and Cheuk-Kwan Sun and Nyuk-Kong Chang and Hon-Kan Yip},
  journal={Chang Gung medical journal},
  year={2008},
  volume={31 2},
  pages={136-44}
}
BACKGROUND Diabetes mellitus (DM) plays a crucial role in the pathogenesis of initiation and propagation of atherosclerosis. Although previous studies have suggested that interactions between cells form the framework for understanding the pathogenesis of atherosclerosis, little is known about how DM impacts intercellular communication within arteries, which occurs via connexin43 (Cx43) gap junctions (GJs). This study tested the hypothesis that DM suppresses expression of Cx43 GJs, and that this… CONTINUE READING