Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.

@article{Baptista2014DiabetesIC,
  title={Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.},
  author={Filipa I Baptista and Maria Joana Pinto and Filipe Elvas and Tiago Martins and Ramiro D. Almeida and Ant{\'o}nio Francisco Ambr{\'o}sio},
  journal={Experimental eye research},
  year={2014},
  volume={127},
  pages={91-103}
}
Diabetic retinopathy is a leading cause of vision loss and blindness. Disruption of axonal transport is associated with many neurodegenerative diseases and might also play a role in diabetes-associated disorders affecting nervous system. We investigated the impact of type 1 diabetes (2 and 8 weeks duration) on KIF1A, KIF5B and dynein motor proteins in the retina. Additionally, since hyperglycemia is considered the main trigger of diabetic complications, we investigated whether prolonged… CONTINUE READING
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