Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.

@article{PorteroOtn1999DiabetesIA,
  title={Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.},
  author={Manuel Portero-Ot{\'i}n and Reinald Pamplona and Maria Cristina Ruiz and Elisa Cabiscol and Joan Prat and Mar{\'i}a Josep Bellmunt},
  journal={Diabetes},
  year={1999},
  volume={48 11},
  pages={2215-20}
}
It is assumed that increased oxidative stress contributes to the development of complications in diabetes. In this study, several markers of protein structural modifications directly induced by free radicals were investigated in the liver and kidney cytosolic fractions of rats with streptozotocin-induced diabetes. Sulfydryl residue and side-chain amino group analyses, as well as immunoblotting and chromatographic measurements of protein-bound carbonyl, suggest that protein oxidative… CONTINUE READING

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