Diabetes-induced renal injury in rats is attenuated by suramin.

@article{Korrapati2012DiabetesinducedRI,
  title={Diabetes-induced renal injury in rats is attenuated by suramin.},
  author={Midhun C. Korrapati and Brooke E. Shaner and Benjamin A. Neely and Joseph L Alge and John M. Arthur and Rick G Schnellmann},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2012},
  volume={343 1},
  pages={
          34-43
        }
}
Progression of hyperglycemia-induced renal injury is a contributing factor for diabetic nephropathy (DN)-induced end-stage renal disease (ESRD), and development of novel therapeutic strategies that act early to prevent progression of DN and ESRD are important. We examined the efficacy and mechanism(s) of suramin on hyperglycemia-induced renal injury before development of overt histological damage. Two groups of male Sprague-Dawley rats received streptozotocin (STZ) and one group received saline… CONTINUE READING

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