Diabetes-induced extracellular matrix protein expression is mediated by transcription coactivator p300.

@article{Kaur2006DiabetesinducedEM,
  title={Diabetes-induced extracellular matrix protein expression is mediated by transcription coactivator p300.},
  author={Harkiran Kaur and Shali Chen and Xiping Xin and Jane Chiu and Zia Ali Khan and Subrata Chakrabarti},
  journal={Diabetes},
  year={2006},
  volume={55 11},
  pages={3104-11}
}
Increased fibronectin expression is a key feature of diabetic angiopathy. We have previously shown that nuclear factor-kappaB (NF-kappaB) mediates fibronectin expression in endothelial cells and in organs affected by diabetes complications. p300, a transcription coactivator, may regulate NF-kappaB activity via poly(ADP-ribose) polymerase (PARP) activation. Hence, we examined the role of p300 in fibronectin expression in diabetes. High glucose induced fibronectin expression in the endothelial… CONTINUE READING