Diabetes-induced dysfunction of the glutamate transporter in retinal Müller cells.

@article{Li2002DiabetesinducedDO,
  title={Diabetes-induced dysfunction of the glutamate transporter in retinal M{\"u}ller cells.},
  author={Qing Li and Donald G. Puro},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 9},
  pages={3109-16}
}
PURPOSE A decrease in the ability of Müller cells to remove glutamate from the extracellular space may play a critical role in the disruption of glutamate homeostasis that occurs in the diabetic retina. Because this amino acid is toxic to retinal neurons and is likely to exacerbate oxidative stress, elucidation of the mechanisms by which glutamate levels are elevated in diabetes may help in the understanding of the pathogenesis of diabetic retinopathy. This study tested the hypothesis that the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 108 extracted citations

Role of interleukin-1β in hypoxia-induced depression of glutamate uptake in retinal Müller cells

Graefe's Archive for Clinical and Experimental Ophthalmology • 2013
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism.

The European journal of neuroscience • 1997
View 4 Excerpts
Highly Influenced

The Retinal Müller Cell

Perspectives in Vision Research • 2002

Similar Papers

Loading similar papers…