Diabetes-induced changes in specific lipid molecular species in rat myocardium.

  title={Diabetes-induced changes in specific lipid molecular species in rat myocardium.},
  author={Xianlin Han and Dana Abendschein and Jeffrey Kelley and Richard W. Gross},
  journal={The Biochemical journal},
  volume={352 Pt 1},
Intrinsic cardiac dysfunction during the diabetic state has been causally linked to changes in myocardial lipid metabolism. However, the precise alterations in the molecular species of myocardial polar and non-polar lipids during the diabetic state and their responses to insulin have not been investigated. Herein we demonstrate four specific alterations in rat myocardial lipid molecular species after induction of the diabetic state by streptozotocin treatment: (i) a massive remodelling of… CONTINUE READING