Diabetes-induced bradycardia is an intrinsic metabolic defect reversed by carnitine.

  title={Diabetes-induced bradycardia is an intrinsic metabolic defect reversed by carnitine.},
  author={Michael Albert Malone and Douglas D. Schocken and Suzan K. Hanna and Xiaomei Liang and John I. Malone},
  journal={Metabolism: clinical and experimental},
  volume={56 8},
Rats with streptozotocin-induced diabetes (STZ-D) have reduced serum carnitine levels and bradycardia. Heart rates (HRs) of 24nondiabetic rats (NRs) and 24 STZ-D rats were compared. L-carnitine (C) was added to the drinking water of rats (12 STZ-D+C) to raise their serum carnitine level. The intrinsic HR for each animal was determined after parasympathetic and sympathetic blockade. The HRs of STZ-D rats (278+/-15 beats per minute) were less than those of NRs (348+/-8 beats per minute) (P<.01… CONTINUE READING
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