Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate.

@article{Zhao2000DiabetesinducedBC,
  title={Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate.},
  author={Weiqiang J Zhao and Palaniyandi S. Devamanoharan and Mark Henein and Abdelmoneim H. Ali and Shambhu D. Varma},
  journal={Diabetes, obesity & metabolism},
  year={2000},
  volume={2 3},
  pages={165-74}
}
AIM Studies have been conducted to determine the effect of pyruvate administration on the biochemistry of rat lens and the status of its transparency as affected by diabetic conditions. METHODS Sprague-Dawley rats were rendered diabetic by intravenous (i.v.) injection of streptozotocin (55 mg/kg body weight (b.w.)) and treated with sodium pyruvate (2%) in drinking water. The levels of glucose, fructose, sorbitol, ATP, GSH, MDA as well as glycated proteins in the lenses were determined at… CONTINUE READING

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