Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.

@article{Ohno2017DiabetesIT,
  title={Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.},
  author={Kouhei Ohno and Atsushi Kuno and Hiromichi Murase and Shingo Muratsubaki and Takayuki Miki and Masaya Tanno and Toshiyuki Yano and Satoko Ishikawa and Tomohisa Yamashita and Tetsuji Miura},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2017},
  volume={313 6},
  pages={H1130-H1142}
}
Acute kidney injury (AKI) after acute myocardial infarction (MI) worsens the prognosis of MI patients. Although type 2 diabetes mellitus (DM) is a major risk factor of AKI after MI, the underlying mechanism remains unclear. Here, we examined the roles of renal Toll-like receptors (TLRs) in the impact of DM on AKI after MI. MI was induced by coronary artery… CONTINUE READING