Diabetes increases the risk of breast cancer: a meta-analysis.

@article{Hardefeldt2012DiabetesIT,
  title={Diabetes increases the risk of breast cancer: a meta-analysis.},
  author={Prue J. Hardefeldt and Senarath Edirimanne and Guy D. Eslick},
  journal={Endocrine-related cancer},
  year={2012},
  volume={19 6},
  pages={
          793-803
        }
}
The aim of this meta-analysis was to collate and analyse all primary observational studies investigating the risk of breast cancer (BC) associated with diabetes. In addition, we aimed to complete subgroup analyses by both type of diabetes and gender of study participants to further clarify the origin of any such association between the two. Studies were obtained from a database search of MEDLINE, EMBASE, PubMed, Current Contents Connect and Google Scholar with additional cross-checking of… 

Figures and Tables from this paper

Association between gestational diabetes mellitus and subsequent risk of cancer: a systematic review of epidemiological studies.

Although GDM increases the risk of certain types of cancer, these results should be interpreted with caution becuase of some methodological flaws.

Diabetes Mellitus as a Risk Factor for Different Types of Cancers: A Systematic Review

A potential link between cancer and diabetes is revealed, however, most of the studies' findings are ambiguous and contradictory, necessitating further investigation to establish the relationship between diabetes and cancer.

Gestational diabetes mellitus and maternal breast cancer risk: a meta-analysis of the literature

  • C. XieWei WangXiuhong LiN. ShaoWeidong Li
  • Medicine, Biology
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2019
GDM during pregnancy is not associated with breast cancer in this study, suggesting that GDM mothers are not needed to be too anxious about their future breast cancer risk.

Diabetes mellitus and prognosis in women with breast cancer

The present meta-analysis suggests that preexisting diabetes is independently associated with poor OS and DFS in female breast cancer patients, and appropriate glycemic control with modification of antihyperglycemic agents can improve the prognosis of female breast cancers patients with diabetes.

Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis

Different statins can reduce the risk of cancer in patients with T2DM, and it is suggested that rosuvastatin may be more effective than others.

Association of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis

The use of metformin may improve overall survival in patients with T2D and breast cancer and Interpretation of results is limited by the observational nature of the studies and resulting biases.

Association of tamoxifen use and increased diabetes among Asian women diagnosed with breast cancer

It is suggested that tamoxifen use in breast cancer patients might increase subsequent diabetes risk, and the underlying mechanism remains unclear and further larger studies are mandatory to validate the findings.

Association of breast cancer and diabetes mellitus in Korean postmenopausal women

It is found that diabetes was associated with increased odds of breast cancer compared to benign breast disease in postmenopausal women in Korea.

Implications of Type1/2 Diabetes Mellitus in Breast Cancer Development: A General Female Population-based Cohort Study

This is the largest cohort study that assesses the possible correlation between both type 1 and 2 diabetes with breast cancer and reveals that diabetes are associated with age, insurance, and region, which further suggest that living condition and life style may be significantly associated with diabetes and breast cancer.

Gestational diabetes mellitus may be associated with increased risk of breast cancer

Women with multiple GDM pregnancies had a higher incidence of breast cancer, suggesting that such women could benefit from increased surveillance for breast cancer.
...

References

SHOWING 1-10 OF 106 REFERENCES

Diabetes mellitus and risk of breast cancer: A meta‐analysis

A meta‐analysis of case–control and cohort studies indicates that diabetes is associated with an increased risk of breast cancer.

Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis.

  • K. PeairsB. Barone A. Wolff
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2011
Compared with their nondiabetic counterparts, patients with breast cancer and pre-existing diabetes have a greater risk of death and tend to present at later stages and receive altered treatment regimens.

Diabetes and risk of incident cancer: a large population-based cohort study in Israel

It is suggested that the nature of the association between DM and cancer depends on sex and specific cancer site, and DM was related with a 47% reduction in the risk of prostate cancer.

Smoking and Breast Cancer: A Meta-Analysis

The results suggest that smoking is a weak risk factor for breast cancer and the risk is higher in the premenopausal period and in those who started smoking at an early age.

Meta-analysis of Studies of Alcohol and Breast Cancer with Consideration of the Methodological Issues

It is confirmed that the association between alcohol and breast cancer may be causal, and findings were robust to study design and analytic approaches in the meta-analyses.

Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan.

Patients with DM drawn from the general Japanese population may be at increased risk of total cancer and of cancer in specific sites.

Increased prevalence of prior breast cancer in women with newly diagnosed diabetes

The results suggest that breast cancer risk may be increased in the pre-diabetes phase and may have implications for screening and prevention strategies.

Metabolic syndrome and the risk of breast cancer in postmenopausal women.

This study supports a direct association between MetS and postmenopausal breast cancer risk, and the risk was higher at older age than previously thought.

Risk of endometrial and breast cancer in patients with diabetes mellitus

It is concluded that compared with the general population, patients with diabetes mellitus have an increased incidence of endometrial and breast cancers.

Diabetes and risk of breast cancer in Asian-American women.

The hypothesis that diabetes may have a role in the development of breast cancer, influencing risk via both sex hormone and insulin pathways is supported.
...