Diabetes in the rat is associated with a reversible postreceptor defect in cholecystokinin action.

@article{Otsuki1984DiabetesIT,
  title={Diabetes in the rat is associated with a reversible postreceptor defect in cholecystokinin action.},
  author={Makoto Otsuki and Ira D Goldfine and John A. Williams},
  journal={Gastroenterology},
  year={1984},
  volume={87 4},
  pages={882-7}
}
Diabetes in the rat is associated with a selective decrease in the sensitivity of pancreatic acini to the secretagogue cholecystokinin. In these animals the concentration of cholecystokinin-33 that maximally stimulates amylase release from isolated pancreatic acini shifts from 300 pM in normal animals to 1 nM in animals made diabetic with streptozotocin. To evaluate the role of the cholecystokinin receptor in this loss of sensitivity, specific 125I-cholecystokinin-33 binding to its receptors on… CONTINUE READING