Diabetes impairs the late inflammatory response to wound healing.

  title={Diabetes impairs the late inflammatory response to wound healing.},
  author={Thomas J. Fahey and A Sadaty and Wright Jones and Annabel E. Barber and Bruce S Smoller and Glen Shires},
  journal={The Journal of surgical research},
  volume={50 4},
Diabetes mellitus is recognized as a risk factor for compromised wound healing. This study examines leukocyte infiltration and the appearance of tumor necrosis factor-alpha (TNF) and IL-6 in wound chambers implanted in normal and streptozotocin-induced diabetic mice. Perforated silicone wound chambers containing a strip of polyvinyl alcohol sponge were implanted along the flanks of normal and diabetic mice. Wound fluid aspirated from the chambers 1, 3, and 7 days following implantation was… CONTINUE READING