Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing.

@article{AlMashat2006DiabetesEM,
  title={Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing.},
  author={Hesham A Al-Mashat and Suneel Kandru and Rongkun Liu and Yugal Behl and Tesfahun Desta and Dana T Graves},
  journal={Diabetes},
  year={2006},
  volume={55 2},
  pages={487-95}
}
We previously reported that after a bacteria-induced wound in the scalp, type 2 diabetic (db/db) mice had higher levels of apoptosis of fibroblasts and bone-lining cells that are critical for healing compared with normoglycemic controls. To investigate mechanisms by which this might occur, RNA profiling and caspase activity was measured after inoculation of Porphyromonas gingivalis. Diabetes caused a more than twofold induction of 71 genes that directly or indirectly regulate apoptosis and… CONTINUE READING

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