Diabetes during pregnancy influences Hofbauer cells, a subtype of placental macrophages, to acquire a pro-inflammatory phenotype.

@article{Sisino2013DiabetesDP,
  title={Diabetes during pregnancy influences Hofbauer cells, a subtype of placental macrophages, to acquire a pro-inflammatory phenotype.},
  author={Giorgia Sisino and Thomas Bouckenooghe and Sandra Aurientis and Pierre Fontaine and L. Storme and Anne Vambergue},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 12},
  pages={1959-68}
}
Growing evidence indicates that maternal pathophysiological conditions, such as diabetes, influence fetal growth and could program metabolic disease in adulthood. Placental cells, particularly Hofbauer cells (HBCs), which are placental macrophages characterized by an anti-inflammatory profile (M2), can sense the modified maternal environment. The goal of this study was to investigate the direct effect of hyperglycemia on HBCs. We studied, at mRNA and protein levels, some markers of M2 and M1… CONTINUE READING
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We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
Growing evidence indicates that maternal pathophysiological conditions , such as diabetes , influence fetal growth and could program metabolic disease in adulthood .
Growing evidence indicates that maternal pathophysiological conditions , such as diabetes , influence fetal growth and could program metabolic disease in adulthood .
Growing evidence indicates that maternal pathophysiological conditions , such as diabetes , influence fetal growth and could program metabolic disease in adulthood .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
GlucoseContraindicated with diseaseHyperglycemia
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
We also noticed that the oxidative - stress pathway was activated in response to high glucose driven by Hif-1α. In this study , we demonstrated that diabetes / hyperglycemia affect the anti - inflammatory profile of HBCs , by stimulating these cells to acquire an inflammatory profile leading to adverse consequences for the fetal - placental - maternal axis .
Growing evidence indicates that maternal pathophysiological conditions , such as diabetes , influence fetal growth and could program metabolic disease in adulthood .
We found that high glucose stimulation activated genes belonging to TLR ( Toll - Like Receptor)-dependent inflammatory pathways .
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