Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex.

@article{Xu2005DiabetesCI,
  title={Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex.},
  author={Yizhen Xu and Brent W. Osborne and Robert C. Stanton},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={289 5},
  pages={F1040-7}
}
The incidence of diabetic nephropathy has been increasing. Studies have shown that oxidative stress (due to increased oxidant production and/or decreased antioxidant activity) is a critical underlying mechanism. The principal intracellular reductant is NADPH whose production is mainly dependent on glucose-6-phosphate dehydrogenase (G6PD) activity. Our work… CONTINUE READING