Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice.

@article{Yu2012DiabetesAA,
  title={Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice.},
  author={Binglan Yu and Chong Lei and David Baron and Andrea U Steinbicker and Kenneth D. Bloch and Warren M. Zapol},
  journal={Transfusion},
  year={2012},
  volume={52 7},
  pages={1410-22}
}
BACKGROUND Stored red blood cells (RBCs) undergo progressive deleterious functional, biochemical, and structural changes. The mechanisms responsible for the adverse effects of transfusing stored RBCs remain incompletely elucidated. STUDY DESIGN AND METHODS Awake wild-type (WT) mice, WT mice fed a high-fat diet (HFD-fed WT) for 4 to 6 weeks, and diabetic (db/db) mice were transfused with syngeneic leukoreduced RBCs or supernatant with or without oxidation (10% of total blood volume) after… CONTINUE READING

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