Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.

  title={Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.},
  author={Angelika Bierhaus and Stephan Schiekofer and Markus Schwaninger and Martin Andrassy and Per M. Humpert and Jin Chen and Meng Hong and Thomas Luther and Thomas Henle and Ingrid Kloeting and M. Morcos and Manfred Hofmann and H. -J. Tritschler and Bernd Weigle and Michael Kasper and Mark E. B. Smith and Giselle Perry and Ann Marie Schmidt and David M. Stern and H. U. H{\"a}ring and Erwin D. Schleicher and Peter P Nawroth},
  volume={50 12},
Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) has been suggested to participate in chronic disorders, such as diabetes and its complications. In contrast to the short and transient activation of NF-kappaB in vitro, we observed a long-lasting sustained activation of NF-kappaB in the absence of decreased IkappaBalpha in mononuclear… CONTINUE READING