Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group.

@article{Sabbah1999DiabetesassociatedAI,
  title={Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group.},
  author={Emmanuelle Sabbah and Kaisa Savola and Petri Kulmala and Riitta K. Veijola and Paula V{\"a}h{\"a}salo and Jouko Karjalainen and Hans K. Akerblom and Mikael Knip},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 5},
  pages={1534-9}
}
We analyzed 747 children, younger than 15 yr of age, with newly diagnosed diabetes, for antibodies to glutamic acid decarboxylase (GADA), the IA-2 protein (IA-2A), insulin (IAA), and islet cells, to evaluate the influence of positivity for GADA, IA-2A, IAA, or multiple (> or = 3) autoantibodies at diagnosis, on the clinical presentation and natural course of the disease over the first 2 yr and to characterize autoantibody-negative patients. At diagnosis, 73.2% of the children tested positive… CONTINUE READING

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