Diabetes as a disease of endoplasmic reticulum stress.

  title={Diabetes as a disease of endoplasmic reticulum stress.},
  author={Sally E. Thomas and Lucy E. Dalton and M Daly and Elke Malzer and Stefan J Marciniak},
  journal={Diabetes/metabolism research and reviews},
  volume={26 8},
Endoplasmic reticulum (ER) stress is an integral part of life for all professional secretory cells, but it has been studied to greatest depth in the pancreatic β-cell. This reflects both the crucial role played by ER stress in the pathogenesis of diabetes and also the exquisite vulnerability of these cells to ER dysfunction. The adaptive cellular response… CONTINUE READING