Diabetes and the peripheral nerve.

@article{Obrosova2009DiabetesAT,
  title={Diabetes and the peripheral nerve.},
  author={Irina G. Obrosova},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1792 10},
  pages={931-40}
}
Diabetes-induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy (PDN), one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation. The pathogenesis of PDN occurs as a consequence of complex interactions among multiple hyperglycemia-initiated mechanisms, impaired insulin signaling, inflammation, hypertension, and disturbances of fatty acid and lipid metabolism. This review describes experimental new findings in… CONTINUE READING

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Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
The pathogenesis of PDN occurs as a consequence of complex interactions among multiple hyperglycemia - initiated mechanisms , impaired insulin signaling , inflammation , hypertension , and disturbances of fatty acid and lipid metabolism .
The pathogenesis of PDN occurs as a consequence of complex interactions among multiple hyperglycemia - initiated mechanisms , impaired insulin signaling , inflammation , hypertension , and disturbances of fatty acid and lipid metabolism .
Peripheral NervesIs primary anatomic site of diseaseDiabetic Neuropathies
Diabetes - induced damage to peripheral nerve culminates in development of peripheral diabetic neuropathy ( PDN ) , one of the most devastating complications of diabetes mellitus and a leading cause of foot amputation .
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