Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.

@article{Lupo2012DiabetesAO,
  title={Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.},
  author={Philip J Lupo and Mark A. Canfield and Claudia Chapa and Wei Lu and Aaron J Agopian and Laura E. Mitchell and Gary M Shaw and Dorothy Kim Waller and Andrew F. Olshan and Richard H. Finnell and Huiping Zhu},
  journal={American journal of epidemiology},
  year={2012},
  volume={176 12},
  pages={1101-9}
}
Few studies have evaluated genetic susceptibility related to diabetes and obesity as a risk factor for neural tube defects (NTDs). The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity. Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study during 1999-2007. Log-linear models were used to evaluate maternal and… CONTINUE READING