Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.

@article{Koster2005DiabetesAI,
  title={Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.},
  author={Joseph C. Koster and M. Alan Permutt and Colin G. Nichols},
  journal={Diabetes},
  year={2005},
  volume={54 11},
  pages={3065-72}
}
The ATP-sensitive K+ channel (K ATP channel) senses metabolic changes in the pancreatic beta-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion. When K ATP channels open, beta-cells hyperpolarize and insulin secretion is suppressed. The prediction that K ATP channel "overactivity" should cause a diabetic state due to undersecretion of insulin has been dramatically borne out by recent genetic studies implicating "activating" mutations in the Kir6.2… CONTINUE READING
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