Diabetes and hypertension in rodent models.

@article{Kloeting1997DiabetesAH,
  title={Diabetes and hypertension in rodent models.},
  author={Ingrid Kloeting and Stacey Berg and Peter Kovacs and Birger Voigt and Lothar Vogt and Stephan Schmidt},
  journal={Annals of the New York Academy of Sciences},
  year={1997},
  volume={827},
  pages={64-84}
}
As shown by ourselves and others, animals models closely resembling human complex diseases like IDDM in BB/OK and hypertension in SHR/Mol rats can be used to dissect a complex disease into discrete genetic factors as has been done for hypertension in (BB/OK x SHR/Mol) cross hybrids. Discrete genetic factors, so-called QTLs, were detected on chromosomes 1, 10, 18, 20, and X. To gain additional information about the physiologic effect of the mapped blood pressure QTLs, genetically defined regions… CONTINUE READING
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