Diabetes and Sarcopenia

  title={Diabetes and Sarcopenia},
  author={Masaki Mogi and Masatsugu Horiuchi},
Diabetes induces muscle atrophy partly caused by an imbalance in contractile protein synthesis and degradation, hyperglycemia, bone marrow microenvironmental defects, and other changes. Muscle atrophy induces functional disability and promotes reduced physical activity. Muscle atrophy also enhances insulin resistance and impairs glucose metabolism. Moreover, sarcopenic obesity has been introduced as a syndrome in older subjects with reduced muscle mass and a change in fat distribution. Fat… CONTINUE READING