Diabetes and Aging-related Complications

  title={Diabetes and Aging-related Complications},
  author={Sho-ichi Yamagishi},
  booktitle={Springer Singapore},
Renal senescence is accompanied by a gradual decrease in its function. Although it rarely causes clinical problems per se, superimposition of various diseases, such as diabetes, may accelerate this functional decline. Recent research has revealed some of the complex mechanisms of how diabetes promotes the aging process in the kidney, including the pathogenic roles of hemodynamic changes, tubulointerstitial hypoxia, oxidative stress, advanced glycation end-products, and impaired autophagy… CONTINUE READING