Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells

@article{Tu2010DiabetesAP,
  title={Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells},
  author={Huiyin Tu and L Zhang and Thai Paul Tran and Robert L. Muelleman and Yu Lei Li},
  journal={Neuroscience},
  year={2010},
  volume={165},
  pages={39-52}
}
Vagal afferent neurons, serving as the primary afferent limb of the parasympathetic reflex, could be involved in diabetic autonomic neuropathy. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the vagal afferent neurons and play an important role in determining cell membrane excitation. In the present study, the protein expression and the electrophysiological characteristics of HCN channels were investigated in nodose ganglion (NG) afferent neurons (A-fiber… CONTINUE READING

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