Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1

@inproceedings{Ha2012DiabetesAR,
  title={Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1},
  author={Yonju Ha and Alan B Saul and Amany M Tawfik and Eric Zorrilla and Vadivel Ganapathy and Sylvia B. Smith},
  booktitle={Molecular vision},
  year={2012}
}
PURPOSE Sigma receptor 1 (σR1) is a non-opioid transmembrane protein that may act as a molecular chaperone at the endoplasmic reticulum-mitochondrial membrane. Ligands for σR1, such as (+)-pentazocine [(+)-PTZ], confer marked retinal neuroprotection in vivo and in vitro. Recently we analyzed the retinal phenotype of mice lacking σR1 (σR1 KO) and observed normal retinal morphology and function in young mice (5-30 weeks) but diminished negative scotopic threshold responses (nSTRs), retinal… CONTINUE READING

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