Diabetes abolishes the vascular protective effects of estrogen in female rats.

@article{Bolego1999DiabetesAT,
  title={Diabetes abolishes the vascular protective effects of estrogen in female rats.},
  author={Chara Bolego and Andrea Cignarella and Valeria Zancan and Christian Pinna and Renata Cristina Onishi Zanardo and Lina Puglisi},
  journal={Life sciences},
  year={1999},
  volume={64 9},
  pages={741-9}
}
Estrogen is known to exert a protective effect against cardiovascular disease. However, women with diabetes have three times the risk as compared with age-matched non-diabetic women. Our previous study on aortic rings of ovariectomized (OVX) female rats treated with 17-beta-estradiol (E2) demonstrated that the beneficial effect of estrogen is related to the… CONTINUE READING