Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes
@article{Maruthur2016DiabetesMA, title={Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes}, author={Nisa M Maruthur and Eva Tseng and Susan M. Hutfless and Lisa M Wilson and Catalina Suarez‐Cuervo and Zackary D Berger and Yue Chu and Emmanuel Iyoha and Jodi B Segal and Shari D. Bolen}, journal={Annals of Internal Medicine}, year={2016}, volume={164}, pages={740-751} }
Type 2 diabetes and its complications are a substantial public health burden, affecting 9.3% of the U.S. adult population (1, 2). Most patients with type 2 diabetes eventually require glucose-lowering pharmacologic therapy, with a goal of reducing long-term complications. More than 7 classes of diabetes medications, which differ in their effects on glucose-lowering, safety, and other important outcomes, are recommended as first- or second-line therapy (3, 4). The Agency for Healthcare Research…
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