Diabetes, oxidative stress and therapeutic strategies.

  title={Diabetes, oxidative stress and therapeutic strategies.},
  author={Luc Rochette and Marianne Zeller and Yves Cottin and Catherine Vergely},
  journal={Biochimica et biophysica acta},
  volume={1840 9},
BACKGROUND Diabetes has emerged as a major threat to health worldwide. SCOPE OF REVIEW The exact mechanisms underlying the disease are unknown; however, there is growing evidence that excess generation of reactive oxygen species (ROS), largely due to hyperglycemia, causes oxidative stress in a variety of tissues. Oxidative stress results from either an increase in free radical production, or a decrease in endogenous antioxidant defenses, or both. ROS and reactive nitrogen species (RNS) are… CONTINUE READING


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